Immunoglobulin motions and antigen binding effects examined by elastic network models
نویسندگان
چکیده
............................................................................................................. ix CHAPTER 1: INTRODUCTION ................................................................................. 1 1.1 Overview of Immunology ................................................................................ 1 1.2 Immunoglobulin Structures ............................................................................. 2 1.3 Elastic Network Models .................................................................................. 5 1.4 A guide to the present study ........................................................................... 6 CHAPTER 2: IMMUNOGLOBULIN CDR MOTIONS ............................................... 8 2.1 Correlation Analysis of IgG structure .............................................................. 9 2.1.1 Methods .................................................................................................... 9 2.1.1.1 Correlated Motions in Normal Modes ................................................. 9 2.1.1.2 Calculation of Combined Effect by Weighting Inverse Eigenvalue ... 10 2.1.2 Results ................................................................................................... 10 2.2 Correlation Analysis for CDR Motions .......................................................... 14 2.3 Similar GNM Computed Correlations for the IgG Structure and the CDRs ... 15 2.4 Changes in Internal Distances ...................................................................... 17 2.4.1 Methods .................................................................................................. 18 2.4.1.1 Computing Changes in Internal Distances for ENMs ....................... 18 2.4.2 Internal Distance Changes of IgG .......................................................... 18 2.5 Local and Global Contributions of Correlations ............................................ 21 2.5.1 Methods .................................................................................................. 21 2.5.1.1 Local Effect ...................................................................................... 21
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تاریخ انتشار 2015